Tamper-Evident Seals for Dietary Supplements

Dietary supplements aren't held to the same tamper-evident rule as OTC drugs — but FDA still requires packaging that protects the product, and a tamper seal is the simplest way to prove it wasn't opened before it reached the customer.

General information, not legal advice — confirm current requirements with FDA guidance or your compliance team.

Tamper Evident Labels

Intertronix's Tamper Evident Labels, VOID Stickers & Security Seals close bottles, jars, and pouches so any opening is immediately visible. They're a stock item, no artwork approval needed, and ship in bulk for supplement brands and co-packers.

Why it matters

FDA's manufacturing rules for dietary supplements (21 CFR 111.70 and 111.410) require packaging that protects the product and matches quality specifications, but they don't spell out a tamper-evident feature the way the rule for OTC drugs does. Most supplement brands add one anyway — it's treated as standard industry practice, and it's one of the easiest ways to reassure a customer that a bottle wasn't opened before it got to them.

Sources: FDA 21 CFR 111.70 · FDA 21 CFR 111.410